Mal-amide-PEG2-oxyamine is widely used in bioconjugation and chemical biology for linking molecules, particularly in the modification of proteins, peptides, and other biomolecules. The maleimide group enables stable covalent bonding with thiol-containing compounds, such as cysteine residues, while the oxyamine moiety facilitates efficient conjugation with aldehydes or ketones through oxime formation, making it valuable for site-specific labeling. The PEG2 spacer enhances water solubility and reduces steric hindrance, improving reaction efficiency. This compound is commonly employed in the development of antibody-drug conjugates, bioconjugate probes, and functionalized nanoparticles for targeted drug delivery, imaging, and diagnostic applications. Its versatility also supports research in protein engineering and the study of biomolecular interactions.