Used as a specialized ligand in homogeneous catalysis, particularly in palladium-catalyzed cross-coupling reactions. Its sterically bulky and electron-rich phosphine groups enhance catalyst stability and reactivity, especially in challenging transformations involving aryl chlorides or sterically hindered substrates. The pentafluorophenyl group contributes to improved solubility in fluorinated solvents and can influence electronic properties of the metal center. It is also employed in catalytic systems where air and moisture stability are important, due to the protective effect of the tert-butyl groups. Commonly applied in C–C and C–heteroatom bond formation in pharmaceutical and agrochemical synthesis.