Used as a key building block in medicinal chemistry, particularly in the design of bioisosteres for phenyl and other aromatic rings. Its rigid, three-dimensional structure improves physicochemical properties of drug candidates, such as solubility and metabolic stability. Commonly incorporated into pharmaceuticals to modulate potency and selectivity, especially in CNS-targeted drugs and kinase inhibitors. Also employed in the development of novel agrochemicals and functional materials due to its unique geometry and polarity.