Used primarily as a bridging reagent in organic synthesis, especially in the preparation of strained hydrocarbon frameworks and bioisosteres. Its unique rigid structure makes it valuable in medicinal chemistry for replacing phenyl or alkyne groups, improving metabolic stability and solubility in drug candidates. Commonly employed in click chemistry and cross-coupling reactions to construct complex 3D molecular architectures. Also utilized in materials science to introduce steric constraints into polymers or small molecules, influencing electronic properties and conformational behavior.