Widely used in medicinal chemistry as a bioisostere for aromatic rings and tert-butyl groups, enhancing metabolic stability and solubility in drug candidates. Its unique strained geometry improves binding selectivity and reduces off-target effects. Commonly employed in the design of CNS-active compounds and kinase inhibitors due to favorable physicochemical properties. Also utilized in agrochemicals to improve environmental stability and potency. Serves as a building block in fragment-based drug discovery and covalent inhibitor development when functionalized appropriately.