Used as a rigid, three-dimensional building block in medicinal chemistry, particularly in the design of bioisosteres to replace phenyl or other aromatic rings. Its unique strained geometry enhances metabolic stability and improves solubility, making it valuable in optimizing drug candidates. Commonly employed in the development of CNS-targeted therapeutics and proteolysis-targeting chimeras (PROTACs) due to its ability to influence molecular conformation and binding selectivity. Also explored in materials science for creating high-stiffness polymers with tailored physical properties.