Widely used in medicinal chemistry as a protecting group strategy for primary amines in synthetic intermediates. The rigid bicyclic structure enhances metabolic stability and improves physicochemical properties of drug candidates. Commonly employed in the development of bioactive molecules, particularly in CNS-targeted therapeutics due to its favorable blood-brain barrier penetration. Also utilized in the synthesis of PROTACs and other bifunctional molecules where steric control and stability are critical. The hydroxymethyl group allows for further functionalization, enabling conjugation or linker attachment in prodrug design and targeted delivery systems.