Used in pharmaceutical research as a rigid bioisostere for phenyl or tert-butyl groups, improving metabolic stability and solubility in drug candidates. Its unique strained bicyclic structure enhances binding selectivity in central nervous system agents and kinase inhibitors. Commonly employed in medicinal chemistry to replace flat aromatic rings, reducing off-target effects and improving pharmacokinetic profiles. Also utilized in the synthesis of novel scaffolds for drug discovery programs targeting neurological disorders and cancer.