Zidebactam sodium salt is primarily used in combination with beta-lactam antibiotics to enhance their effectiveness against resistant bacterial strains. It functions as a beta-lactamase inhibitor, preventing the breakdown of beta-lactam antibiotics by bacterial enzymes, thereby restoring their antibacterial activity. This makes it particularly valuable in treating infections caused by multidrug-resistant Gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii. Its application is critical in clinical settings where traditional antibiotics fail, offering a therapeutic option for severe and hard-to-treat infections.