Zidebactam is primarily used as a beta-lactamase inhibitor in combination with other antibiotics to enhance their effectiveness against resistant bacterial infections. It works by preventing the breakdown of beta-lactam antibiotics, such as penicillins and cephalosporins, by bacterial enzymes. This makes it a valuable component in treating infections caused by multidrug-resistant Gram-negative bacteria, including strains of Pseudomonas aeruginosa and Acinetobacter baumannii. Its application is particularly significant in hospital settings for managing complicated urinary tract infections, pneumonia, and bloodstream infections where traditional antibiotics may fail.