2-Chloro-5-iodobenzonitrile is primarily used as an intermediate in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. Its structure allows it to participate in various coupling reactions, such as Suzuki or Sonogashira couplings, which are essential for creating complex molecules. The compound is also utilized in the development of active pharmaceutical ingredients (APIs) due to its halogenated aromatic ring, which can enhance biological activity. Additionally, it serves as a building block in the synthesis of herbicides and fungicides, contributing to its role in agricultural chemistry. Its versatility in chemical reactions makes it a valuable component in research and industrial applications.