N-tert-Butyl-2-iodobenzamide is primarily used in organic synthesis as a versatile intermediate for constructing complex molecules. Its iodine atom makes it a valuable substrate in cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings, which are essential in pharmaceutical and materials science research. The tert-butyl group provides steric hindrance, enabling selective transformations in multi-step synthetic pathways. Additionally, it serves as a precursor in the development of bioactive compounds, including potential drug candidates, due to its ability to introduce functional groups at specific positions in organic frameworks. Its applications also extend to the synthesis of agrochemicals and advanced materials, where precise molecular design is critical.