A-1210477 is a selective inhibitor of Mcl-1, a protein involved in regulating apoptosis (programmed cell death). It is primarily used in cancer research to target tumor cells that overexpress Mcl-1, which is common in certain types of leukemia, lymphoma, and solid tumors. By inhibiting Mcl-1, A-1210477 promotes cancer cell death and enhances the effectiveness of other anti-cancer agents, especially Bcl-2 inhibitors like venetoclax. It serves as a valuable tool in studying resistance mechanisms in cancer therapy and is used in preclinical studies to develop combination treatments aimed at overcoming drug resistance. Its application is mainly confined to laboratory research and early-stage drug development.