Azido-PEG8-TFP ester is widely used in bioconjugation and chemical biology for its reactive properties. The azide group enables click chemistry reactions, particularly copper-catalyzed azide-alkyne cycloaddition (CuAAC), which is essential for labeling biomolecules like proteins, peptides, and nucleic acids. The TFP ester group reacts efficiently with primary amines, allowing for covalent attachment to amine-containing molecules. This makes it valuable for modifying surfaces, creating drug delivery systems, and developing bioimaging probes. Its PEG spacer enhances solubility and reduces steric hindrance, improving the efficiency of conjugation processes in research and therapeutic applications.