Azido-PEG4-alpha-D-mannose is widely used in bioconjugation and chemical biology research. Its azide group enables click chemistry reactions, particularly copper-catalyzed azide-alkyne cycloaddition (CuAAC), making it valuable for labeling and modifying biomolecules. This compound is often employed in glycobiology studies to introduce mannose moieties into proteins, lipids, or other molecules, facilitating the investigation of carbohydrate-protein interactions. It is also utilized in the development of targeted drug delivery systems, where mannose receptors on specific cells can be exploited for precise targeting. Additionally, it plays a role in the synthesis of glycoconjugates for vaccine development and diagnostic applications. Its PEG4 spacer enhances solubility and reduces steric hindrance, improving the efficiency of conjugation processes.