Acetylazide is primarily used in organic synthesis as a versatile reagent for introducing azide groups into molecules. It is particularly valuable in click chemistry, where it participates in azide-alkyne cycloaddition reactions to form triazoles, which are important in drug discovery and material science. Additionally, acetylazide serves as a precursor in the preparation of other azide compounds, which are useful in the development of pharmaceuticals, agrochemicals, and polymers. Its reactivity also makes it a key component in the synthesis of energetic materials and explosives.