AMG-900 is primarily used in the field of cancer research, particularly as a potent and selective inhibitor of Aurora kinases. These kinases play a crucial role in cell division and are often overexpressed in various cancers. By inhibiting Aurora kinases, AMG-900 disrupts the mitotic process, leading to the arrest of cancer cell proliferation and induction of apoptosis. This makes it a valuable tool in preclinical studies to understand the mechanisms of tumor growth and to evaluate potential therapeutic strategies. Additionally, it is being explored for its potential in combination therapies, where it may enhance the efficacy of other anticancer agents. Its application extends to studying drug resistance mechanisms in cancer cells, providing insights into overcoming treatment challenges.