L-161,982 is primarily used in research settings as a selective antagonist for the angiotensin II type 2 (AT2) receptor. It plays a significant role in studying the physiological and pathological functions of the AT2 receptor, which is involved in various processes such as blood pressure regulation, cell growth, and tissue repair. Researchers utilize L-161,982 to investigate its potential therapeutic effects in conditions like hypertension, cardiovascular diseases, and fibrosis. Additionally, it helps in understanding the contrasting roles of AT1 and AT2 receptors in the renin-angiotensin system, contributing to the development of targeted treatments for related disorders. Its application is largely confined to experimental studies aimed at elucidating receptor mechanisms and exploring novel drug candidates.