2-Iodophenylacetonitrile is primarily used in organic synthesis as a versatile intermediate. It serves as a key building block in the preparation of various pharmaceuticals, particularly in the synthesis of active pharmaceutical ingredients (APIs) that target neurological and cardiovascular disorders. Its iodine moiety makes it a valuable substrate for cross-coupling reactions, such as Suzuki and Sonogashira couplings, which are essential for constructing complex organic molecules. Additionally, it is employed in the development of agrochemicals, contributing to the creation of herbicides and pesticides. Its nitrile group also allows for further functionalization, enabling the production of amides, acids, and other derivatives used in fine chemical manufacturing.