4-Biphenylyl trifluoromethanesulfonate is widely used as a reagent in organic synthesis, particularly in cross-coupling reactions. It serves as an effective electrophile in palladium-catalyzed reactions, such as the Suzuki-Miyaura coupling, to form biaryl compounds. These biaryl structures are essential in the development of pharmaceuticals, agrochemicals, and materials science. Additionally, its triflate group is highly reactive, making it a valuable intermediate for introducing biphenyl moieties into complex molecules. Its stability and reactivity also make it suitable for use in the synthesis of liquid crystals and organic electronic materials.