1,5-Naphthalenebis(trifluoromethanesulfonate) is primarily used as a versatile reagent in organic synthesis, particularly in the formation of carbon-carbon and carbon-heteroatom bonds. Its strong electron-withdrawing properties make it an effective activator for various coupling reactions, such as Suzuki-Miyaura and Heck reactions, enabling the synthesis of complex organic molecules. Additionally, it serves as a key intermediate in the preparation of advanced materials, including polymers and liquid crystals, due to its ability to introduce trifluoromethanesulfonate groups, which enhance thermal and chemical stability. In pharmaceutical research, it is employed to modify bioactive compounds, improving their potency and selectivity. Its reactivity also makes it valuable in the development of agrochemicals and specialty chemicals.