1,4-Naphthalenebis(trifluoromethanesulfonate) is primarily utilized as a versatile reagent in organic synthesis, particularly in the formation of carbon-carbon and carbon-heteroatom bonds. Its strong electron-withdrawing properties make it an effective activator in cross-coupling reactions, enabling the synthesis of complex organic molecules. It is also employed in the preparation of naphthalene derivatives, which are valuable intermediates in the production of pharmaceuticals, agrochemicals, and materials science applications. Additionally, its triflate groups serve as excellent leaving groups, facilitating nucleophilic substitution reactions in the development of functionalized aromatic compounds.