1-Fluoro-2-iodo-4-(trifluoromethyl)benzene
95%
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description Product Description
Used as a key intermediate in the synthesis of pharmaceuticals and agrochemicals, particularly in reactions where selective functionalization of aromatic rings is required. Its mixed halogen substituents (fluoro and iodo) allow for sequential cross-coupling reactions, enabling the construction of complex molecules. The electron-withdrawing trifluoromethyl group enhances reactivity in nucleophilic aromatic substitution and stabilizes certain reaction intermediates. Commonly employed in the development of fluorinated bioactive compounds, where the fluorine and iodine moieties serve as handles for further transformation via palladium-catalyzed coupling or radiofluorination for PET imaging probes.
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