1-Chloro-4-iodobenzene is primarily used as an intermediate in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. Its structure allows for further functionalization, making it valuable in cross-coupling reactions, such as Suzuki and Sonogashira couplings, to create complex organic molecules. It is also employed in the development of liquid crystals and advanced materials due to its aromatic and halogenated properties. Additionally, it serves as a precursor in the synthesis of dyes and pigments, contributing to the coloration industry. Its reactivity with various reagents makes it a versatile compound in research and industrial applications.