1-Bromo-2,4,5-trifluoro-3-methylbenzene
95%
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Used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, particularly in the development of fluorinated organic compounds. Its structure, featuring a bromine leaving group ortho to a fluorine and with additional fluorines at para and meta positions, allows for selective functionalization in cross-coupling reactions, making it valuable in building complex molecules for drug discovery. Commonly employed in Suzuki and Heck reactions to introduce the 2,4,5-trifluoro-3-methylphenyl group into target compounds. The polyfluorinated motif enhances lipophilicity and metabolic stability, desirable for bioactive molecules. Also utilized in the preparation of liquid crystals and functional materials where fluorinated aromatic cores enhance thermal and chemical stability.
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