Used as a chiral building block in the synthesis of biologically active compounds, particularly in pharmaceuticals where stereochemistry plays a critical role. Its phosphoramidate group enables incorporation into prodrug strategies, enhancing cellular uptake of nucleotide analogs. Commonly applied in antiviral drug development, especially for modifying pharmacokinetic properties of active agents. Also serves as an intermediate in asymmetric synthesis, leveraging the chiral center for selective reactions. Useful in medicinal chemistry for structure-activity relationship studies involving phosphorus-containing analogs.