Dolutegravir (GSK1349572)
10mM in DMSO
Reagent
Code: #168685
CAS Number
1051375-16-6
blur_circular Chemical Specifications
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Molecular Information
Weight
419.38 g/mol
Formula
C₂₀H₁₉F₂N₃O₅
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Storage & Handling
Storage
-20°C
description Product Description
Used in the treatment of HIV-1 infection as part of antiretroviral therapy. It is an integrase inhibitor that blocks the viral integrase enzyme, preventing the integration of viral DNA into the host genome, thereby stopping the replication of the virus. Commonly prescribed in combination with other antiretroviral agents for both treatment-naïve and treatment-experienced patients. Known for high genetic barrier to resistance, making it effective in suppressing viral load even in cases with some drug resistance. Also used in prevention strategies such as post-exposure prophylaxis in certain settings.
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