Arterolane is primarily used in the treatment of malaria, particularly in combination with piperaquine. It is effective against Plasmodium falciparum, the parasite responsible for the most severe form of malaria. The combination therapy is known for its rapid action in reducing parasite load and alleviating symptoms such as fever and chills. It is especially valuable in regions where resistance to other antimalarial drugs, like chloroquine, is prevalent. The drug is administered orally, making it convenient for use in both clinical settings and remote areas. Its short treatment course improves patient compliance and helps in controlling malaria outbreaks efficiently.