2,6-Di-tert-butyl-4-methylpyridine is a sterically hindered pyridine derivative used primarily as a non-nucleophilic base in organic synthesis. The bulky tert-butyl groups at the 2- and 6-positions prevent nucleophilic side reactions and strong coordination to metals or Lewis acids, making it ideal for acid scavenging, enol triflate formation, peptide coupling, and other sensitive transformations. It is also utilized as a ligand in organometallic catalysis and in the synthesis of pharmaceuticals and fine chemicals.