1-O-Methylnataloe-emodin, a derivative of the anthraquinone emodin from aloe plants, is utilized in pharmaceutical and biochemical research due to its multifaceted bioactivities. It exhibits potential anti-inflammatory, antimicrobial, and antioxidant properties, with demonstrated activity against certain bacterial and fungal strains, positioning it as a candidate for novel antimicrobial agents. Its antioxidant effects, stemming from structural similarity to anthraquinones, help protect cells from free radical damage. Additionally, it is investigated for cytotoxic effects on cancer cell lines, indicating possible oncology applications. Ongoing studies explore its use in health care products and cosmetics for anti-aging and wrinkle reduction. Its natural product origins support exploration in drug discovery, though human trials are limited.