Clerodenoside A exhibits significant anti-inflammatory activity by inhibiting pro-inflammatory cytokines such as TNF-α and IL-6. It has been studied for its potential in managing chronic inflammatory conditions, including arthritis and inflammatory bowel disease. The compound also demonstrates moderate antioxidant properties, contributing to cellular protection against oxidative stress. Recent in vitro studies suggest possible neuroprotective effects, making it a candidate for further research in neurodegenerative disorders like Alzheimer’s disease. Additionally, clerodenoside A shows weak to moderate antimicrobial activity against certain Gram-positive bacteria, indicating a potential role as a lead compound in developing new antimicrobial agents. Its natural origin and biological profile support interest in its use as a phytochemical marker in herbal medicine standardization.