Cyclo(-Ala-His) is a stable cyclic dipeptide utilized in biochemical and pharmaceutical research due to its potential as an enzyme inhibitor, particularly for enzymes involved in inflammation and chronic diseases. Studies have shown antioxidant properties that protect cells, including nerve cells, from oxidative stress, making it promising for developing treatments for neurological disorders such as Alzheimer's. It also serves as a model for studying the structure and stability of synthetic peptides under various conditions. In skincare formulations, it helps protect skin cells from oxidative stress and environmental damage, enhances collagen synthesis for improved elasticity and reduction of fine lines, exhibits potential anti-glycation effects to prevent age-related skin deterioration, and promotes wound healing while reducing inflammation in dermatological applications.