Betulin palmitate is used in cosmetic and pharmaceutical formulations for its skin-conditioning and protective properties. It exhibits emollient characteristics, helping to soften and smooth the skin by forming a protective barrier that reduces moisture loss. Due to its lipophilic nature, it enhances the penetration of active ingredients through the skin, making it useful in transdermal delivery systems. It is also investigated for its potential anti-inflammatory, antioxidant, and anti-cancer effects, supporting its use in skincare products targeting aging, irritation, or environmental damage, as well as potential medical applications. Additionally, betulin palmitate has shown mild antimicrobial activity, which can contribute to the preservation and efficacy of topical products.