Mafenide is primarily used as an antimicrobial agent in the treatment of burns. It is applied topically to prevent and treat infections in second- and third-degree burn wounds. The compound is effective against a broad spectrum of bacteria, including Pseudomonas aeruginosa, which is commonly associated with burn wound infections. Mafenide works by penetrating the eschar, the dead tissue that forms over burns, providing a protective barrier against bacterial colonization. It is often used in burn units and emergency care settings to reduce the risk of sepsis and promote healing. Additionally, mafenide is sometimes employed in the management of other types of wounds, such as skin grafts or traumatic injuries, where infection control is critical. Its ability to inhibit bacterial growth while allowing the wound to heal makes it a valuable tool in burn care and wound management.