Lomefloxacin is widely used in the treatment of bacterial infections, particularly those affecting the urinary tract, respiratory system, and skin. Its broad-spectrum antibacterial activity makes it effective against a variety of Gram-negative and some Gram-positive bacteria. In urology, it is often prescribed for uncomplicated urinary tract infections due to its ability to concentrate in the urine. It is also utilized in respiratory infections such as bronchitis and pneumonia, where it targets the causative pathogens effectively. Additionally, lomefloxacin is employed in ophthalmology as an eye drop solution to treat bacterial conjunctivitis and corneal ulcers. Its use in surgical prophylaxis, especially in procedures with a risk of postoperative infections, highlights its role in preventing bacterial complications. However, its application is carefully monitored due to potential side effects, including photosensitivity and tendon issues.