Used primarily for the prevention and treatment of malaria, especially in regions where chloroquine resistance is prevalent. It is effective against the blood stages of Plasmodium falciparum and Plasmodium vivax, helping to suppress symptoms and reduce transmission. Often prescribed for travelers visiting endemic areas due to its once-weekly dosing regimen, which improves adherence. Also used in combination with other antimalarials in certain treatment protocols. Its long half-life allows for extended protection after leaving a malaria-prone region. However, due to potential neuropsychiatric side effects, it is not recommended for long-term use or for individuals with a history of mental health disorders.