Aricine is primarily used in the pharmaceutical industry as an intermediate in the synthesis of antimalarial drugs. It plays a key role in the development of derivatives of artemisinin, enhancing the efficacy and stability of treatments against Plasmodium species, including drug-resistant strains. Due to its peroxide bridge structure, it contributes to the generation of free radicals within parasite cells, leading to oxidative stress and pathogen death. It is also investigated for potential antiviral and anticancer applications, particularly in targeting tumor cells with high iron concentrations, which can activate its cytotoxic properties. Additionally, aricine derivatives are explored for use in combination therapies to reduce treatment duration and prevent resistance development.