Arteether is a semi-synthetic derivative of artemisinin primarily used as an antimalarial drug, particularly for the treatment of severe and complicated cases of malaria caused by Plasmodium falciparum. It is administered via intramuscular injection as an oil-based solution, ensuring rapid absorption and effective action against the malaria parasite. Arteether works by generating free radicals that target the parasite's ability to metabolize hemoglobin, leading to its death. It is especially valuable in regions where resistance to other antimalarial drugs, such as chloroquine, is prevalent. Due to its efficacy and relatively fast action, it is often employed in emergency settings or for patients who cannot take oral medications. However, its use is typically limited to short-term treatment due to potential side effects, including neurotoxicity risks, and the need for careful monitoring.