JNJ-39758979 is primarily investigated for its potential therapeutic applications in treating allergic and inflammatory conditions. It functions as a histamine H4 receptor antagonist, which plays a key role in modulating immune responses and inflammation. This compound has been studied for its efficacy in alleviating symptoms of conditions such as asthma, atopic dermatitis, and allergic rhinitis. By blocking the H4 receptor, it may reduce inflammation, itching, and other allergic reactions, offering a targeted approach to managing these disorders. Research continues to explore its full potential in clinical settings.