3-(6-Chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride
95%
Reagent
Code: #74414
CAS Number
188416-20-8
blur_circular Chemical Specifications
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Molecular Information
Weight
420.22 g/mol
Formula
C₁₆H₁₄Cl₂F₃N₅O
thermostat
Physical Properties
Melting Point
126-130°C
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Storage & Handling
Storage
room temperature, dry
description Product Description
This compound serves as a key intermediate in the synthesis of voriconazole, a triazole antifungal agent used in medicinal chemistry. Voriconazole targets fungal enzymes involved in ergosterol biosynthesis, essential for fungal cell membrane integrity, thereby inhibiting fungal growth and treating infections such as candidiasis and aspergillosis. The hydrochloride salt form of this intermediate enhances solubility, facilitating its use in pharmaceutical synthesis. Ongoing research explores applications against drug-resistant fungal strains through derivatives like voriconazole.
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