Pleionesin C exhibits significant antifungal activity, particularly against plant pathogenic fungi, making it a potential candidate for agricultural fungicides. It has been studied for its ability to inhibit mycelial growth in fungi such as Fusarium and Botrytis species, which are responsible for crop diseases and post-harvest spoilage. Due to its natural origin and targeted bioactivity, Pleionesin C is also being explored for use in eco-friendly pest management strategies and as a lead compound in developing new antifungal agents in both agriculture and pharmaceuticals.