(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol with methanesulfonate

97%

Reagent Code: #113153
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CAS Number 1175536-50-1

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 365.35 g/mol
Formula C₁₃H₁₇F₂N₃O₅S
inventory_2 Storage & Handling
Storage room temperature, stored under inert gas

description Product Description

This compound is a key chiral intermediate in the synthesis of triazole-based antifungal medications, such as those in the azole class (e.g., related to itraconazole or ketoconazole derivatives). The final drugs produced using this intermediate inhibit lanosterol 14α-demethylase, disrupting ergosterol biosynthesis essential for fungal cell membranes. This leads to increased permeability, leakage, and death of fungal cells, making them effective against pathogens like Candida species and Aspergillus. The specific (2R,3R) stereoisomer ensures proper configuration for downstream reactions. Its methanesulfonate salt form provides enhanced solubility and stability for use in pharmaceutical manufacturing processes. Research also explores its role in developing antifungal coatings for medical devices to prevent biofilm formation and colonization.

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Test Parameter Specification
Appearance White to yellow powder or crystals
Purity (%) 96.5-100
Infrared Spectrum Conforms To Structure
NMR Conforms To Structure

shopping_cart Available Sizes & Pricing

Size Availability Unit Price Quantity
inventory 10g
10-20 days ฿7,780.00
inventory 1g
10-20 days ฿1,300.00
inventory 250mg
10-20 days ฿570.00
inventory 5g
10-20 days ฿4,260.00

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