(2R,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol
97%
Reagent
Code: #113140
CAS Number
133775-25-4
blur_circular Chemical Specifications
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Molecular Information
Weight
269.25 g/mol
Formula
C₁₂H₁₃F₂N₃O₂
thermostat
Physical Properties
Boiling Point
485.0±55.0°C at 760 mmHg
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Storage & Handling
Storage
2-8°C, store under inert gas
description Product Description
This compound serves as a key intermediate in the pharmaceutical industry for the synthesis of triazole antifungal agents. It possesses a 1,2,4-triazole ring and a 2,4-difluorophenyl substituent, structural features typical of azole antifungals that target ergosterol biosynthesis in fungal cells, disrupting membrane integrity. The (2R,3R) configuration is crucial for the stereoselectivity in downstream reactions leading to active pharmaceuticals effective against a broad spectrum of fungi, including Candida and Aspergillus species. It is employed in the development of formulations such as oral, topical, and intravenous drugs for treating systemic and localized fungal infections.
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