Used in the prevention of nausea and vomiting associated with highly emetogenic chemotherapy, including cisplatin-based treatments. It is also effective in preventing postoperative nausea and vomiting. Administered intravenously, the compound acts as a neurokinin-1 (NK1) receptor antagonist, blocking substance P in the central nervous system. Commonly used in combination with other antiemetics like 5-HT3 receptor antagonists and corticosteroids for enhanced efficacy. Particularly beneficial in patients undergoing cancer treatment where control of chemotherapy-induced nausea is critical for treatment adherence and quality of life.