(S)-18-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-19,19-dimethyl-16-oxo-4,7,10,13-tetraoxa-17-azaicosan-1-oic acid
95%
Reagent
Code: #233419
CAS Number
2172820-12-9
blur_circular Chemical Specifications
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Molecular Information
Weight
706.85 g/mol
Formula
C₃₄H₅₀N₄O₁₀S
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Registry Numbers
MDL Number
MFCD32693336
thermostat
Physical Properties
Boiling Point
950.9±65.0 °C(Predicted)
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Storage & Handling
Density
1.254±0.06 g/cm3(Predicted)
Storage
-20°C, away from light, dry
description Product Description
Used in pharmaceutical research as a key intermediate in the synthesis of GLP-1 receptor agonists, particularly in the development of long-acting antidiabetic drugs. Its structure enables conjugation with proteins or peptides to enhance stability and prolong half-life in vivo. Commonly employed in the preparation of semaglutide analogs due to its ability to facilitate albumin binding through fatty acid side chain mimicry, improving pharmacokinetic properties. Also utilized in prodrug strategies where controlled release of the active moiety is required. Its polyethylene glycol (PEG) spacer units enhance solubility and reduce aggregation, making it suitable for subcutaneous formulations.
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