Used in the management of type 2 diabetes mellitus, acetohexamide helps control blood glucose levels by stimulating insulin release from the pancreas. It is typically prescribed as an adjunct to diet and exercise for patients whose hyperglycemia cannot be controlled by lifestyle changes alone. This medication is particularly useful in individuals who are not insulin-dependent and can maintain some level of endogenous insulin production. It may also be used in combination with other antihyperglycemic agents to achieve optimal glycemic control. Due to its long duration of action, it allows for once-daily dosing in many patients, improving adherence. However, its use has declined with the availability of newer sulfonylureas with more favorable safety and pharmacokinetic profiles.