Glyhexamide is primarily used in the treatment of diabetes mellitus, specifically type 2 diabetes. It functions as an oral hypoglycemic agent, helping to lower blood sugar levels by stimulating the pancreas to release insulin. This action aids in the regulation of glucose metabolism, making it effective for managing hyperglycemia in diabetic patients. It is often prescribed as part of a comprehensive treatment plan that includes diet and exercise. Additionally, glyhexamide may be used in combination with other antidiabetic medications to achieve better glycemic control. Its role in improving insulin sensitivity makes it a valuable option for patients who do not respond adequately to lifestyle modifications alone.