Zopolrestat is primarily used in the treatment of diabetic complications, particularly diabetic neuropathy. It functions as an aldose reductase inhibitor, which helps in reducing the accumulation of sorbitol in nerve cells. This accumulation is a key factor in the development of nerve damage in diabetic patients. By inhibiting aldose reductase, Zopolrestat helps in alleviating symptoms associated with diabetic neuropathy, such as pain, numbness, and tingling in the extremities. Additionally, it has been explored for its potential in preventing or slowing the progression of other diabetic complications, including retinopathy and nephropathy, by mitigating the harmful effects of high blood sugar on various tissues and organs.