Levomilnacipran hydrochloride is primarily used as an antidepressant in the treatment of major depressive disorder (MDD). It works by increasing the levels of serotonin and norepinephrine in the brain, which helps improve mood, energy levels, and overall sense of well-being.

In clinical practice, it is prescribed to adults to alleviate symptoms such as persistent sadness, loss of interest in daily activities, fatigue, and difficulty concentrating. Its extended-release formulation allows for once-daily dosing, enhancing patient compliance.

Additionally, it may be considered for patients who have not responded adequately to other antidepressants, as it offers a unique balance of serotonin and norepinephrine reuptake inhibition. However, it is important to monitor for potential side effects, including increased blood pressure, heart rate changes, and gastrointestinal disturbances.

It is not recommended for use in children, adolescents, or individuals with certain medical conditions without careful evaluation by a healthcare provider.