Lofepramine is primarily used in the treatment of depression, particularly for cases where other antidepressants have not been effective. It works by increasing the levels of certain neurotransmitters in the brain, such as serotonin and norepinephrine, which helps to improve mood and reduce feelings of sadness and anxiety. This medication is often prescribed for individuals experiencing major depressive disorder, and it can also be beneficial in managing symptoms of anxiety that often accompany depression. Due to its relatively favorable side effect profile compared to older tricyclic antidepressants, it is sometimes preferred for patients who may be sensitive to more severe side effects. It is typically administered orally, and the dosage is carefully adjusted based on the patient's response and tolerance. Regular monitoring is essential to ensure the effectiveness and safety of the treatment.